Welcome to the shared landing site for NIH Common Fund Transformative High Resolution Cryo-Electron Microscopy Program Centers.
First established in 2018, multiple centers located across the US aim to broaden access to high-resolution cryo-electron microscopy (cryoEM) and tomography (cryoET) for biomedical researchers through instrumentation access at national service centers, and cultivation of a skilled workforce through the development and implementation of cryoEM training material.
This site provides an overview of the different centers to help you navigate these resources and links to each of the centers own websites for more information.
Our centers are organized into three areas:
CryoEM Centers
The three National cryoEM Service Centers offer usage of state-of-the-art equipment, technical support, and cross-training for the production and analysis of high-resolution data. These offerings are available at no charge for non-profit use, eliminating the high cost barrier usually associated with cryoEM.
CryoET Centers
The National Network for CryoET comprises four centers that provide access to advanced instrumentation for cryoET specimen preparation, collection of high-resolution cryoET data, and cross-training in cryoET methods.
Curriculum Development
Curriculum Development Program sites are developing open access instructional material on cryoEM for those with or without a structural biology background.
Upcoming events of note:
-
Thursday, March 27, 2025: Adam Oken, Oregon Health and Science University will present Small-Molecule Modulation of the P2X7 Receptor Revealed by Cryo-EM as part of the CryoEM Current Practices webinar 9 AM pacific/12 PM eastern time. More details and registration on our Events page.
-
Join the national centers for a user gathering at the Microscopy & Microanalysis (M&M) annual meeting. We are organizing a pre-meeting congress: X61 – Transformative High-Resolution Cryo-Electron Microscopy on Sunday July 25, 2025. We hope you will come spend some time with us there.