Welcome to the shared landing site for NIH Common Fund Transformative High Resolution Cryo-Electron Microscopy Program Centers.

First established in 2018, multiple centers located across the US aim to broaden access to high-resolution cryo-electron microscopy (cryoEM) and tomography (cryoET) for biomedical researchers through instrumentation access at national service centers, and cultivation of a skilled workforce through the development and implementation of cryoEM training material.

This site provides an overview of the different centers to help you navigate these resources and links to each of the centers own websites for more information.

Our centers are organized into three areas:

CryoEM Centers

The three National cryoEM Service Centers offer usage of state-of-the-art equipment, technical support, and cross-training for the production and analysis of high-resolution data. These offerings are available at no charge for non-profit use, eliminating the high cost barrier usually associated with cryoEM.

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CryoET Centers

The four newly established centers make up the National Network for CryoET to provide the access to advanced instrumentation for cryoET, cryoET specimen preparation, and collection of high-resolution cryoET data as well as cross-training in cryoET methods.

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Curriculum Development

Curriculum Development Program sites are developing open access instructional material on cryoEM for those with or without a structural biology background.

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Upcoming events of note:

October 28, 2021: CryoEM Current Practices webinar 9 AM pacific/12 PM eastern time. Speaker: Helen Donelick. Talk title: Structural determination of the Dicer-2•R2D2 complex. More details here. Register here.

December 9, 2021: CryoEM Current Practices webinar 9 AM pacific/12 PM eastern time. Speaker: Tarjani Thaker. Talk title: Determining structural mechanisms of allosteric regulation in ABCC family transporters using a remote cryo-EM pipeline. More details here. Register here.

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